Whole blood microRNAs as potential biomarkers in post-operative early breast cancer patients.

ABSTRACT:

Background

microRNAs (miRNAs) are considered promising cancer biomarkers, showing high reliability, sensitivity and stability. Our study aimed to identify associations between whole blood miRNA profiles, presence of circulating tumor cells (CTCs) and clinical outcome in post-operative early breast cancer patients (EBC) to assess the utility of miRNAs as prognostic markers in this setting.

Method

A total of 48 post-operative patients, recruited in frame of the SUCCESS A trial, were included in this retrospective study and tested with a panel of 8 miRNAs (miR-10b, -19a, - 21, - 22, -20a, - 127, - 155, -200b). Additional 17 female healthy donors with no previous history of cancer were included in the study as negative controls. Blood samples were collected at different time poi

SUBMITTER: Alunni-Fabbroni M 

PROVIDER: S-EPMC5802058 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature