Exploring the potential of 3D Zernike descriptors and SVM for protein-protein interface prediction.

ABSTRACT:

Background

The correct determination of protein-protein interaction interfaces is important for understanding disease mechanisms and for rational drug design. To date, several computational methods for the prediction of protein interfaces have been developed, but the interface prediction problem is still not fully understood. Experimental evidence suggests that the location of binding sites is imprinted in the protein structure, but there are major differences among the interfaces of the various protein types: the characterising properties can vary a lot depending on the interaction type and function. The selection of an optimal set of features characterising the protein interface and the development of an effective method to represent and capture the complex protein recognition pa

SUBMITTER: Daberdaku S 

PROVIDER: S-EPMC5802066 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature