Identification of differentially expressed genes and regulatory relationships in Huntington's disease by bioinformatics analysis.

ABSTRACT: Huntington's disease (HD) is an inherited, progressive neurodegenerative disease caused by a CAG expansion in the huntingtin (HTT) gene; various dysfunctions of biological processes in HD have been proposed. However, at present the exact pathogenesis of HD is not fully understood. The present study aimed to explore the pathogenesis of HD using a computational bioinformatics analysis of gene expression. GSE11358 was downloaded from the Gene Expression Omnibus andthe differentially expressed genes (DEGs) in the mutant HTT knock‑in cell model STHdhQ111/Q111 were predicted. DEGs between the HD and control samples were screened using the limma package in R. Functional and pathway enrichment analyses were conducted using the database for annotation, visualization and integrated discovery softwar

SUBMITTER: Dong X 

PROVIDER: S-EPMC5802203 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature