Tunable Microfibers Suppress Fibrotic Encapsulation via Inhibition of TGFβ Signaling.

ABSTRACT: Fibrotic encapsulation limits the efficacy and lifetime of implantable biomedical devices. Microtopography has shown promise in the regulation of myofibroblast differentiation, a key driver of fibrotic encapsulation. However, existing studies have not systematically isolated the requisite geometric parameters for suppression of myofibroblast differentiation via microtopography, and there has not been in vivo validation of this technology to date. To address these issues, a novel lamination method was developed to afford more control over topography dimensions. Specifically, in this study we focus on fiber length and its effect on myofibroblast differentiation. Fibroblasts cultured on films with microfibers exceeding 16 μm in length lost the characteristic morphology associated with myofibr

SUBMITTER: Allen J 

PROVIDER: S-EPMC5802271 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature