Prostate Specific Membrane Antigen Targeted ¹⁸F-DCFPyL Positron Emission Tomography/Computerized Tomography for the Preoperative Staging of High Risk Prostate Cancer: Results of a Prospective, Phase II, Single Center Study.

ABSTRACT:

Purpose

We prospectively evaluated the diagnostic performance of prostate specific membrane antigen targeted ¹⁸F-DCFPyL positron emission tomography/computerized tomography in the preoperative staging of men at high risk for harboring metastatic prostate cancer despite a negative conventional staging evaluation.

Materials and methods

Men with clinically localized high or very high risk prostate cancer were imaged with ¹⁸F-DCFPyL positron emission tomography/computerized tomography before undergoing radical prostatectomy with standardized pelvic lymph node dissection. The scans were interpreted by 2 blinded nuclear medicine readers and assessed for interreader variability as well as diagnostic accuracy for pelvic lymph node staging. Surgical pathology se

SUBMITTER: Gorin MA 

PROVIDER: S-EPMC5802365 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature