Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches.

ABSTRACT: Progressive supranuclear palsy (PSP), previously believed to be a common cause of atypical parkinsonism, is now recognised as a range of motor and behavioural syndromes that are associated with a characteristic 4-repeat tau neuropathology. New research criteria that recognise early presentations of PSP and operationalise diagnosis of the full spectrum of clinical phenotypes have been reported. The Movement Disorders Society PSP diagnostic criteria include syndromes with few or mild symptoms that are suggestive of underlying PSP pathology and could provide an opportunity for earlier therapeutic interventions in the future. These criteria also include definitions for variant PSP syndromes with different patterns of movement, language, or behavioural features than have been conclusively assoc

SUBMITTER: Boxer AL 

PROVIDER: S-EPMC5802400 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature