Biology, Mechanism, and Structure of Enzymes in the α-d-Phosphohexomutase Superfamily.

ABSTRACT: Enzymes in the α-d-phosphohexomutases superfamily catalyze the reversible conversion of phosphosugars, such as glucose 1-phosphate and glucose 6-phosphate. These reactions are fundamental to primary metabolism across the kingdoms of life and are required for a myriad of cellular processes, ranging from exopolysaccharide production to protein glycosylation. The subject of extensive mechanistic characterization during the latter half of the 20th century, these enzymes have recently benefitted from biophysical characterization, including X-ray crystallography, NMR, and hydrogen-deuterium exchange studies. This work has provided new insights into the unique catalytic mechanism of the superfamily, shed light on the molecular determinants of ligand recognition, and revealed the evolutionary cons

SUBMITTER: Stiers KM 

PROVIDER: S-EPMC5802415 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature