The relationship between dlPFC activity during unpredictable threat and CO₂-induced panic symptoms.

ABSTRACT: Panic disorder is characterized by sudden, repeated, and unexpected attacks of intense fear and overwhelming anxiety about when another attack may strike. Patients with panic disorder and healthy individuals with a history of panic attacks show a hypersensitivity to unpredictable threats, suggesting a possible link between panic and sustained anxiety. The purpose of this study was to determine the degree to which induced symptoms of panic relate to fear and anxiety, as well as activity in the neural systems that mediate and regulate these affective states. Psychological and physiological symptoms of panic were assessed during an 8-min 7.5% CO₂ challenge task. Psychological, physiological, and neural symptoms of fear and anxiety were measured during two sessions (one psychophysio

SUBMITTER: Balderston NL 

PROVIDER: S-EPMC5802456 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature