Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling.

ABSTRACT: Schizophrenia patients have an increased risk of cardiac dysfunction. A possible factor underlying this comorbidity are the common variants in the large set of genes that have recently been discovered in genome-wide association studies (GWASs) as risk genes of schizophrenia. Many of these genes control the cell electrogenesis and calcium homeostasis. We applied biophysically detailed models of layer V pyramidal cells and sinoatrial node cells to study the contribution of schizophrenia-associated genes on cellular excitability. By including data from functional genomics literature to simulate the effects of common variants of these genes, we showed that variants of voltage-gated Na⁺ channel or hyperpolarization-activated cation channel-encoding genes cause qualitatively similar e

SUBMITTER: Maki-Marttunen T 

PROVIDER: S-EPMC5802468 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature