Assessment of p16 expression and HPV infection in adenoid cystic carcinoma of the lacrimal gland.

ABSTRACT:

Purpose

Adenoid cystic carcinoma (ACC) in the lacrimal gland is a rare malignancy. P16 is encoded by the CDKN2A gene, which is recognized as a tumor suppressor due to its inactivation in many types of tumors. However, p16 overexpression is also linked to adverse tumor parameters. These contradictory observations have also been confirmed in ACCs in the salivary glands. Furthermore, evidence of human papilloma virus (HPV) infection is found in a proportion of ACCs in the salivary glands. P16 is often overexpressed in HPV-related squamous cell carcinoma in parallel. To our knowledge, the role of p16 and HPV in ACCs in the lacrimal gland is still unknown.

Methods

Twenty-one ACCs in the lacrimal gland and ten matched healthy lacrimal glands were studied. P16 was detected w

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5802570 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature