Association between serum neuron-specific enolase, age, overweight, and structural MRI patterns in 901 subjects.

ABSTRACT: Serum neuron-specific enolase (sNSE) is considered a marker for neuronal damage, related to gray matter structures. Previous studies indicated its potential as marker for structural and functional damage in conditions with adverse effects to the brain like obesity and dementia. In the present study, we investigated the putative association between sNSE levels, body mass index (BMI), total gray matter volume (GMV), and magnetic resonance imaging-based indices of aging as well as Alzheimer's disease (AD)-like patterns.

Subjects/methods

sNSE was determined in 901 subjects (499 women, 22-81 years, BMI 18-48 kg/m²), participating in a population-based study (SHIP-TREND). We report age-specific patterns of sNSE levels between males and females. Females showed augmenting, males

SUBMITTER: Hoffmann J 

PROVIDER: S-EPMC5802579 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature