Fluid resuscitation with lactated Ringer's solution vs normal saline in acute pancreatitis: A triple-blind, randomized, controlled trial.

ABSTRACT:

Background

Little is known regarding the optimal type of fluid resuscitation in acute pancreatitis (AP).

Objective

The objective of this article was to compare the effect of lactated Ringer's solution (LR) vs normal saline (NS) in the inflammatory response in AP.

Methods

We conducted a triple-blind, randomized, controlled trial. Patients ≥ 18 admitted with AP were eligible. Patients were randomized to receive LR or NS. Primary outcome variables were number of systemic inflammatory response syndrome (SIRS) criteria at 24 hours, 48 hours and 72 hours and blood C-reactive protein (CRP) levels at 48 hours and 72 hours. In vitro complementary experiments were performed to further explore the interaction between pH, lactate and inflammation.

Results

Nineteen patients

SUBMITTER: de-Madaria E 

PROVIDER: S-EPMC5802674 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature