Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders.

ABSTRACT: Bipolar disorder (BPD) and major depressive disorder (MDD) are primary major mood disorders. Recent studies suggest that they share certain psychopathological features and common risk genes, but unraveling the full genetic architecture underlying the risk of major mood disorders remains an important scientific task. The public genome-wide association study (GWAS) data sets offer the opportunity to examine this topic by utilizing large amounts of combined genetic data, which should ultimately allow a better understanding of the onset and development of these illnesses. Genome-wide meta-analysis was performed by combining two GWAS data sets on BPD and MDD (19,637 cases and 18,083 controls), followed by replication analyses for the loci of interest in independent 12,364 cases and 76,633 contr

SUBMITTER: Xiao X 

PROVIDER: S-EPMC5802692 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature