Gender-specific alteration of energy balance and circadian locomotor activity in the Crtc1 knockout mouse model of depression.

ABSTRACT: Obesity and depression are major public health concerns, and there is increasing evidence that they share etiological mechanisms. CREB-regulated transcription coactivator 1 (CRTC1) participates in neurobiological pathways involved in both mood and energy balance regulation. Crtc1 ^-/- mice rapidly develop a depressive-like and obese phenotype in early adulthood, and are therefore a relevant animal model to explore possible common mechanisms underlying mood disorders and obesity. Here, the obese phenotype of male and female Crtc1 ^-/- mice was further characterized by investigating CRTC1's role in the homeostatic and hedonic regulation of food intake, as well as its influence on daily locomotor activity. Crtc1 ^-/- mice showed a strong gender difference in the

SUBMITTER: Rossetti C 

PROVIDER: S-EPMC5802703 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature