Proliferation dynamics of acute myeloid leukaemia and haematopoietic progenitors competing for bone marrow space.

ABSTRACT: Leukaemia progressively invades bone marrow (BM), outcompeting healthy haematopoiesis by mechanisms that are not fully understood. Combining cell number measurements with a short-timescale dual pulse labelling method, we simultaneously determine the proliferation dynamics of primitive haematopoietic compartments and acute myeloid leukaemia (AML). We observe an unchanging proportion of AML cells entering S phase per hour throughout disease progression, with substantial BM egress at high levels of infiltration. For healthy haematopoiesis, we find haematopoietic stem cells (HSCs) make a significant contribution to cell production, but we phenotypically identify a quiescent subpopulation with enhanced engraftment ability. During AML progression, we observe that multipotent progenitors maintain

SUBMITTER: Akinduro O 

PROVIDER: S-EPMC5802720 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature