Effects of diet composition on weight loss, metabolic factors and biomarkers in a 1-year weight loss intervention in obese women examined by baseline insulin resistance status.

ABSTRACT:

Background

Obesity is a risk factor for postmenopausal breast cancer incidence and premenopausal and postmenopausal breast cancer mortality, which may be explained by several metabolic and hormonal factors (sex hormones, insulin resistance, and inflammation) that are biologically related. Differential effects of dietary composition on weight loss and these metabolic factors may occur in insulin-sensitive vs. insulin-resistant obese women.

Objective

To examine the effect of diet composition on weight loss and metabolic, hormonal and inflammatory factors in overweight/obese women stratified by insulin resistance status in a 1-year weight loss intervention.

Methods and results

Nondiabetic women who were overweight/obese (n=245) were randomly assigned to a lower fat (20%

SUBMITTER: Rock CL 

PROVIDER: S-EPMC5802865 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature