Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light.

ABSTRACT: The sarcomere is an exquisitely designed apparatus that is capable of generating force, which in the case of the heart results in the pumping of blood throughout the body. At the molecular level, an ATP-dependent interaction of myosin with actin drives the contraction and force generation of the sarcomere. Over the past six decades, work on muscle has yielded tremendous insights into the workings of the sarcomeric system. We now stand on the cusp where the acquired knowledge of how the sarcomere contracts and how that contraction is regulated can be extended to an understanding of the molecular mechanisms of sarcomeric diseases, such as hypertrophic cardiomyopathy (HCM). In this review we present a picture that combines current knowledge of the myosin mesa, the sequestered state of myosin

SUBMITTER: Trivedi DV 

PROVIDER: S-EPMC5803174 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature