Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8⁺ TCR-Vβ⁺ expansions.

ABSTRACT: CD8⁺ T-cell expansions are the primary manifestation of T-cell large granular lymphocytic leukemia (T-LGLL), which is frequently accompanied by neutropenia and rheumatoid arthritis, and also occur as a secondary phenomenon in leukemia patients treated with dasatinib, notably in association with various drug-induced side-effects. However, the mechanisms that underlie the genesis and maintenance of expanded CD8⁺ T-cell receptor (TCR)-Vβ⁺ populations in these patient groups have yet to be fully defined. In this study, we performed a comprehensive phenotypic and clonotypic assessment of expanded (TCR-Vβ⁺) and residual (TCR-Vβ^-) CD8⁺ T-cell populations in T-LGLL and dasatinib-treated chronic myelogenous leukemia (CML) patients. T

SUBMITTER: Lissina A 

PROVIDER: S-EPMC5803196 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature