Impact of brain shift on subcallosal cingulate deep brain stimulation.

ABSTRACT:

Background

Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) is an emerging experimental therapy for treatment-resistant depression. New developments in SCC DBS surgical targeting are focused on identifying specific axonal pathways for stimulation that are estimated from preoperatively collected diffusion-weighted imaging (DWI) data. However, brain shift induced by opening burr holes in the skull may alter the position of the target pathways.

Objectives

Quantify the effect of electrode location deviations on tractographic representations for stimulating the target pathways using longitudinal clinical imaging datasets.

Methods

Preoperative MRI and DWI data (planned) were coregistered with postoperative MRI (1 day, near-term) and CT (3 weeks, long-term) da

SUBMITTER: Choi KS 

PROVIDER: S-EPMC5803301 | biostudies-literature | 2018 Mar - Apr

REPOSITORIES: biostudies-literature