Early-life environmental exposures interact with genetic susceptibility variants in pediatric patients with eosinophilic esophagitis.

ABSTRACT:

Background

Although eosinophilic esophagitis (EoE) is associated with certain gene variants, the rapidly increasing incidence of EoE suggests that environmental factors contribute to disease development.

Objective

We tested for gene-environment interaction between EoE-predisposing polymorphisms (within TSLP, LOC283710/KLF13, CAPN14, CCL26, and TGFB) and implicated early-life factors (antibiotic use in infancy, cesarean delivery, breast-feeding, neonatal intensive care unit [NICU] admission, and absence of pets in the home).

Methods

We conducted a case-control study using hospital-based cases (n = 127) and control subjects representative of the hospital catchment area (n = 121). We computed case-only interaction tests and in secondary analyses evaluated the combined an

SUBMITTER: Jensen ET 

PROVIDER: S-EPMC5803324 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature