Visceral Adiposity in Psoriasis is Associated With Vascular Inflammation by ¹⁸F-Fluorodeoxyglucose Positron-Emission Tomography/Computed Tomography Beyond Cardiometabolic Disease Risk Factors in an Observational Cohort Study.

ABSTRACT:

Objectives

The authors sought to examine the relationship between visceral adipose tissue (VAT) and vascular inflammation (VI) by ¹⁸F-Fluorodeoxyglucose (¹⁸F-FDG) positron-emission tomography (PET)/computed tomography (CT) in psoriasis (PSO). Furthermore, we evaluated whether treatment of PSO modulated VAT and VI.

Background

PSO, a chronic inflammatory skin disease, is associated with VI by ¹⁸F-FDG PET/CT and increased cardiometabolic risk including adipose tissue dysregulation. Recently, VI was associated with future cardiovascular events; however, the relationship of visceral and subcutaneous adiposity with VI in PSO has yet to be evaluated.

Methods

Consecutive PSO patients (N = 77) underwent ¹⁸F-FDG PET/CT scans to measur

SUBMITTER: Rivers JP 

PROVIDER: S-EPMC5803350 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature