Age is a predictor of a small decrease in lung function in children with sickle cell anemia.

ABSTRACT: The longitudinal pattern of lung function in children with sickle cell anemia (SCA) has shown a decrease in FEV₁ % predicted, a risk factor for death in adults with SCA, but predictors for this decline are poorly characterized. In a prospective longitudinal multi-center cohort of children with SCA, we tested the hypotheses that: (1) FEV₁ % predicted declines over time; and (2) SCA-specific characteristics and therapy predict this decline. At three clinical centers, children with SCA (HbSS or HbSβ⁰ thalassemia), unselected for respiratory disease, were enrolled in the Sleep and Asthma Cohort (SAC) study. Study-certified pulmonary function technicians performed spirometry and lung volumes. Each assessment was reviewed centrally. Predicted values were determin

SUBMITTER: Willen SM 

PROVIDER: S-EPMC5803370 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature