3D Maskless Micropatterning for Regeneration of Highly Organized Tubular Tissues.

ABSTRACT: Micropatterning is a widely used powerful tool to create highly ordered microstructures on material surfaces. However, due to technical limitations, the integration of micropatterned microstructures into bioinspired 3D scaffolds to successfully regenerate well-organized functional tissues is not achieved. In this work, a unique maskless micropatterning technology is reported to create 3D nanofibrous matrices with highly organized tubular architecture for tissue regeneration. This micropatterning method is a laser-guided, noncontact, high-precision, flexible computer programming of machining process that can create highly ordered tubules with the density ranged from 1000 to 60 000 mm^-2 and the size varied from 300 nm to 30 µm in the bioinspired 3D matrix. The tubular architecture

SUBMITTER: Ma C 

PROVIDER: S-EPMC5803393 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature