Intensity ratio to improve black hole assessment in multiple sclerosis.

ABSTRACT:

Background

Improved imaging methods are critical to assess neurodegeneration and remyelination in multiple sclerosis. Chronic hypointensities observed on T1-weighted brain MRI, "persistent black holes," reflect severe focal tissue damage. Present measures consist of determining persistent black holes numbers and volumes, but do not quantitate severity of individual lesions.

Objective

Develop a method to differentiate black and gray holes and estimate the severity of individual multiple sclerosis lesions using standard magnetic resonance imaging.

Methods

38 multiple sclerosis patients contributed images. Intensities of lesions on T1-weighted scans were assessed relative to cerebrospinal fluid intensity using commercial software. Magnetization transfer imaging, diffusio

SUBMITTER: Adusumilli G 

PROVIDER: S-EPMC5803396 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature