Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent.

ABSTRACT:

Scope

Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption.

Methods and results

A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10^-7) , and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-anal

SUBMITTER: Smith CE 

PROVIDER: S-EPMC5803424 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature