Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms.

ABSTRACT:

Objective

To determine whether the extent of overlap of the genetic architecture among the sporadic late-onset Alzheimer's Disease (sLOAD), familial late-onset AD (fLOAD), sporadic early-onset AD (sEOAD), and autosomal dominant early-onset AD (eADAD).

Methods

Polygenic risk scores (PRSs) were constructed using previously identified 21 genome-wide significant loci for LOAD risk.

Results

We found that there is an overlap in the genetic architecture among sEOAD, fLOAD, and sLOAD. The highest association of the PRS and risk (odds ratio [OR] = 2.27; P = 1.29 × 10^-7) was observed in sEOAD, followed by fLOAD (OR = 1.75; P = 1.12 × 10^-7) and sLOAD (OR = 1.40; P = 1.21 × 10^-3). The PRS was associated with cerebrospinal fluid ptau₁₈₁-

SUBMITTER: Cruchaga C 

PROVIDER: S-EPMC5803427 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature