Sex hormones are negatively associated with vertebral bone marrow fat.

ABSTRACT:

Context

Higher bone marrow fat (BMF)¹ is associated with osteoporosis and reduced hematopoiesis. Exogenous estradiol reduces BMF in older women, but effects of endogenous sex hormones are unknown.

Objective

To determine if endogenous sex hormones are associated with BMF in older men and women.

Design, setting and participants

Cross-sectional study in the Age Gene/Environment Susceptibility (AGES) Reykjavik cohort. Participants using medications that may affect BMF were excluded.

Main outcome measures

Vertebral BMF was measured with magnetic resonance spectroscopy. Estradiol, testosterone and sex hormone binding globulin were measured on archived serum. Linear regression models were adjusted for age, total percent body fat and visit window.

Results

SUBMITTER: Mistry SD 

PROVIDER: S-EPMC5803453 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature