Differentially expressed alternatively spliced genes in skeletal muscle from cancer patients with cachexia.

ABSTRACT:

Background

Alternative splicing (AS) is a post-transcriptional gene regulatory mechanism that contributes to proteome diversity. Aberrant splicing mechanisms contribute to various cancers and muscle-related conditions such as Duchenne muscular dystrophy. However, dysregulation of AS in cancer cachexia (CC) remains unexplored. Our objectives were (i) to profile alternatively spliced genes (ASGs) on a genome-wide scale and (ii) to identify differentially expressed alternatively spliced genes (DASGs) associated with CC.

Methods

Rectus abdominis muscle biopsies obtained from cancer patients were stratified into cachectic cases (n = 21, classified based on International consensus diagnostic framework for CC) and non-cachectic controls (n = 19, weight stable cancer patients). Huma

SUBMITTER: Narasimhan A 

PROVIDER: S-EPMC5803615 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature