Ontology highlight
ABSTRACT:
SUBMITTER: Chen D
PROVIDER: S-EPMC5803789 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Biology of reproduction 20170101 6
In humans, germline competency and the specification of primordial germ cells (PGCs) are thought to occur in a restricted developmental window during early embryogenesis. Despite the importance of specifying the appropriate number of PGCs for human reproduction, the molecular mechanisms governing PGC formation remain largely unexplored. Here, we compared PGC-like cell (PGCLC) differentiation from 18 independently derived human embryonic stem cell (hESC) lines, and discovered that the expression ...[more]