Elucidating mechanistic insights into drug action for atopic dermatitis: a systems biology approach.

ABSTRACT:

Background

Topical Betamethasone (BM) and Pimecrolimus (PC) are widely used drugs in the treatment of atopic dermatitis (AD). Though the biomolecules and biological pathways affected by the drugs are known, the causal inter-relationships among these pathways in the context of skin is not available. We aim to derive this insight by using transcriptomic data of AD skin samples treated with BM and PC using systems biology approach.

Methods

Transcriptomic datasets of 10 AD patients treated with Betamethasone and Pimecrolimus were obtained from GEO datasets. We used a novel computational platform, eSkIN ( www.persistent.com/eskin ), to perform pathway enrichment analysis for the given datasets. eSkIN consists of 35 skin specific pathways, thus allowing skin-centric analysis of tr

SUBMITTER: Subramanian I 

PROVIDER: S-EPMC5803917 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature