Characterizing undiagnosed chronic obstructive pulmonary disease: a systematic review and meta-analysis.

ABSTRACT:

Background

A significant proportion of patients with chronic obstructive pulmonary disease (COPD) remain undiagnosed. Characterizing these patients can increase our understanding of the 'hidden' burden of COPD and the effectiveness of case detection interventions.

Methods

We conducted a systematic review and meta-analysis to compare patient and disease factors between patients with undiagnosed persistent airflow limitation and those with diagnosed COPD. We searched MEDLINE and EMBASE for observational studies of adult patients meeting accepted spirometric definitions of COPD. We extracted and pooled summary data on the proportion or mean of each risk factor among diagnosed and undiagnosed patients (unadjusted analysis), and coefficients for the adjusted association between r

SUBMITTER: Johnson KM 

PROVIDER: S-EPMC5803996 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature