Ulk4 regulates GABAergic signaling and anxiety-related behavior.

ABSTRACT: Excitation/inhibition imbalance has been proposed as a fundamental mechanism in the pathogenesis of neuropsychiatric and neurodevelopmental disorders, in which copy number variations of the Unc-51 like kinase 4 (ULK4) gene encoding a putative Serine/Threonine kinase have been reported in approximately 1/1000 of patients suffering pleiotropic clinical conditions of schizophrenia, depression, autistic spectrum disorder (ASD), developmental delay, language delay, intellectual disability, or behavioral disorder. The current study characterized behavior of heterozygous Ulk4 ^+/tm1a mice, demonstrating that Ulk4 ^+/tm1a mice displayed no schizophrenia-like behavior in acoustic startle reactivity and prepulse inhibition tests or depressive-like behavior in the Porsolt swim or

SUBMITTER: Liu M 

PROVIDER: S-EPMC5804027 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature