Effect of nutrient supplementation on the acquisition of humoral immunity to Plasmodium falciparum in young Malawian children.

ABSTRACT: BACKGROUND:There is evidence that suggests that undernutrition has a detrimental effect on malarial immunity in children. The aim of the study was to discover whether nutrient supplementation improved development of malarial antibody immunity in children up to 18 months of age. METHODS:The study was conducted with a subset of 432 Malawian children from a randomized controlled trial of nutritional supplements. The arms included pre- and postnatal small-quantity lipid-based nutrient supplements for both mother and child; prenatal supplementation with iron and folic acid; and pre- and postnatal supplementation with multiple micronutrients. Paired plasma samples were collected at 6 and 18 months of age. The levels of antibodies against merozoite surface protein 1 (MSP1 19kD) and MSP2, erythroc

SUBMITTER: Barua P 

PROVIDER: S-EPMC5804088 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature