Nerve Fiber Flux Analysis Using Wide-Field Swept-Source Optical Coherence Tomography.

ABSTRACT:

Purpose

To devise a method to quantify nerve fibers over their arcuate courses over an extended peripapillary area using optical coherence tomography (OCT).

Methods

Participants were imaged with 8 × 8-mm volumetric OCT scans centered at the optic disc. A new quantity, nerve fiber flux (NFF), represents the cross-sectional area transected perpendicular to the nerve fibers. The peripapillary area was divided into 64 tracks with equal flux. An iterative algorithm traced the trajectory of the tracks assuming that the relative distribution of the NFF was conserved with compensation for fiber connections to ganglion cells on the macular side. Average trajectory was averaged from normal eyes and use to calculate the NFF maps for glaucomatous eyes. The NFF maps were divided into eig

SUBMITTER: Tan O 

PROVIDER: S-EPMC5804304 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature