Linking pangenomes and metagenomes: the Prochlorococcus metapangenome.

ABSTRACT: Pangenomes offer detailed characterizations of core and accessory genes found in a set of closely related microbial genomes, generally by clustering genes based on sequence homology. In comparison, metagenomes facilitate highly resolved investigations of the relative distribution of microbial genomes and individual genes across environments through read recruitment analyses. Combining these complementary approaches can yield unique insights into the functional basis of microbial niche partitioning and fitness, however, advanced software solutions are lacking. Here we present an integrated analysis and visualization strategy that provides an interactive and reproducible framework to generate pangenomes and to study them in conjunction with metagenomes. To investigate its utility, we applied

SUBMITTER: Delmont TO 

PROVIDER: S-EPMC5804319 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature