Gene Expression Profile of the Clinically Aggressive Micropapillary Variant of Bladder Cancer.

ABSTRACT:

Background

Progression of conventional urothelial carcinoma of the bladder to a tumor with unique microscopic features referred to as micropapillary carcinoma is coupled with aggressive clinical behavior signified by a high propensity for metastasis to regional lymph nodes and distant organs resulting in shorter survival.

Objective

To analyze the expression profile of micropapillary cancer and define its molecular features relevant to clinical behavior.

Design, setting, and participants

We retrospectively identified 43 patients with micropapillary bladder cancers and a reference set of 89 patients with conventional urothelial carcinomas and performed whole-genome expression messenger RNA profiling.

Outcome measurements and statistical analysis

The tumors were s

SUBMITTER: Guo CC 

PROVIDER: S-EPMC5804336 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature