Dataset Information

Targeted Delivery of the HLA-B^∗27-Binding Peptide into the Endoplasmic Reticulum Suppresses the IL-23/IL-17 Axis of Immune Cells in Spondylarthritis.

ABSTRACT: Ankylosing spondylitis (AS) is highly associated with the expression of human leukocyte antigen-B27 (HLA-B^∗27). HLA-B^∗27 heavy chain (B27-HC) has an intrinsic propensity to fold slowly, leading to the accumulation of the misfolded B27-HC in the endoplasmic reticulum (ER) and formation of the HLA-B^∗27 HC homodimer, (B27-HC)₂, by a disulfide linkage at Cys-67. (B27-HC)₂ displayed on the cell surface can act as a ligand of the killer-cell Ig-like receptor (KIR3DL2). (B27-HC)₂ binds to KIR3DL2 of NK and Th17 cells and activates both cells, resulting in the activation of the IL-23/IL-17 axis to launch the inflammatory reaction in AS patients. However, activation of the IL-23/IL-17 axis originally derived from the HLA-B^∗

SUBMITTER: Yu HC

PROVIDER: S-EPMC5804395 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Dataset Information

Targeted Delivery of the HLA-B^∗27-Binding Peptide into the Endoplasmic Reticulum Suppresses the IL-23/IL-17 Axis of Immune Cells in Spondylarthritis.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Targeted Delivery of the HLA-B∗27-Binding Peptide into the Endoplasmic Reticulum Suppresses the IL-23/IL-17 Axis of Immune Cells in Spondylarthritis.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Targeted Delivery of the HLA-B^∗27-Binding Peptide into the Endoplasmic Reticulum Suppresses the IL-23/IL-17 Axis of Immune Cells in Spondylarthritis.