Potential Adverse Effects of Broad-Spectrum Antimicrobial Exposure in the Intensive Care Unit.

ABSTRACT:

Background

The potential adverse effects of empiric broad-spectrum antimicrobial use among patients with suspected but subsequently excluded infection have not been fully characterized. We sought novel methods to quantify the risk of adverse effects of broad-spectrum antimicrobial exposure among patients admitted to an intensive care unit (ICU).

Methods

Among all adult patients admitted to ICUs at a single institution, we selected patients with negative blood cultures who also received ≥1 broad-spectrum antimicrobials. Broad-spectrum antimicrobials were categorized in ≥1 of 5 categories based on their spectrum of activity against potential pathogens. We performed, in serial, 5 cohort studies to measure the effect of each broad-spectrum category on patient outcomes. Exposed p

SUBMITTER: Wiens J 

PROVIDER: S-EPMC5804637 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature