High-Yielding Automated Convergent Synthesis of No-Carrier-Added [¹¹C-Carbonyl]-Labeled Amino Acids Using the Strecker Reaction.

ABSTRACT: A new variant of the Strecker synthesis using no-carrier-added [¹¹C]cyanide for the synthesis of radiolabeled amino acids is described. The protocol is fully automated using a radiochemistry synthesis module and applied to the production of a number of new PET radiotracers. [¹¹C-Carbonyl]sarcosine, [¹¹C-carbonyl]methionine, [¹¹C-carbonyl]-N-phenylglycine, and [¹¹C-carbonyl]glycine are all synthesized in moderate to good radiochemical yields. The synthesis of [¹¹C-carbonyl]sarcosine has been validated for production of doses for clinical use, and preliminary evaluation of the new radiotracer in PC3 tumor-bearing mice is also reported.

SUBMITTER: Xing J 

PROVIDER: S-EPMC5804752 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature