Nutrition Influences Caffeine-Mediated Sleep Loss in Drosophila.

ABSTRACT:

Study objectives

Plant-derived caffeine is regarded as a defensive compound produced to prevent herbivory. Caffeine is generally repellent to insects and often used to study the neurological basis for aversive responses in the model insect, Drosophila melanogaster. Caffeine is also studied for its stimulatory properties where sleep or drowsiness is suppressed across a range of species. Since limiting access to food also inhibits fly sleep-an effect known as starvation-induced sleep suppression-we tested whether aversion to caffeinated food results in reduced nutrient intake and assessed how this might influence fly studies on the stimulatory effects of caffeine.

Methods

We measured sleep and total consumption during the first 24 hours of exposure to caffeinated diets contain

SUBMITTER: Keebaugh ES 

PROVIDER: S-EPMC5804985 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature