Mechanisms of vascular comorbidity in autoimmune diseases.

ABSTRACT: PURPOSE OF REVIEW:Persuasive statistics support the clinical observation that because of cardiovascular comorbidities patients with inflammatory joint disease die significantly earlier despite anti-inflammatory therapy. RECENT FINDINGS:The reason for this earlier death is multifactorial and involves a combination of a complex genetic background, environmental influences, classical cardiovascular risk factors and the impact of anti-inflammatory therapy. We will describe the importance of several new mechanisms, especially the diverse intercellular communication routes including extracellular vesicles and microRNAs that support the development of cardiovascular comorbidities. SUMMARY:The aim of this review is to give an updated overview about the known risk factors in the development of card

SUBMITTER: Nagy G 

PROVIDER: S-EPMC5805124 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature