Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.

ABSTRACT:

Objectives

The majority of drug dosing studies are based on adult populations, with modification of the dosing for children based on size and weight. This rudimentary approach for drug dosing children is limited, as biologically a child can differ from an adult in far more aspects than just size and weight. Specifically, understanding the ontogeny of childhood liver development is critical in dosing drugs that are metabolized through the liver, as the rate of metabolism determines the duration and intensity of a drug's pharmacologic action. Therefore, we set out to determine pharmacogenes that change over childhood development, followed by a secondary agnostic analysis, assessing changes transcriptome wide.

Materials and methods

A total of 47 human liver tissue samples, with

SUBMITTER: Meier R 

PROVIDER: S-EPMC5805126 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature