Ontology highlight
ABSTRACT:
SUBMITTER: Eisenstein A
PROVIDER: S-EPMC5805139 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Melanoma research 20180201 1
There is a significant need for the development of diagnostic tools that can precisely distinguish Spitz nevi and spitzoid melanomas. Here, we report the development of a PCR-based quantitative diagnostic assay for spitzoid melanocytic lesions utilizing the expression ratio of neuropilin-2 and melan-A genes in primary tumor specimens. We find that the expression ratio of neuropilin-2/melan-A is significantly increased in spitzoid melanomas compared with Spitz nevi. The diagnostic potential of th ...[more]