Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes.

ABSTRACT: Virus reprogramming of cellular metabolism is recognised as a critical determinant for viral growth. While most viruses appear to activate central energy metabolism, different viruses have been shown to rely on alternative mechanisms of metabolic activation. Whether related viruses exploit conserved mechanisms and induce similar metabolic changes is currently unclear. In this work we investigate how two alphaviruses, Semliki Forest virus and Ross River virus, reprogram host metabolism and define the molecular mechanisms responsible. We demonstrate that in both cases the presence of a YXXM motif in the viral protein nsP3 is necessary for binding to the PI3K regulatory subunit p85 and for activating AKT. This leads to an increase in glucose metabolism towards the synthesis of fatty acids, al

SUBMITTER: Mazzon M 

PROVIDER: S-EPMC5805360 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature