Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.

ABSTRACT:

Background

Dementia with Lewy bodies is the second most common form of dementia in elderly people but has been overshadowed in the research field, partly because of similarities between dementia with Lewy bodies, Parkinson's disease, and Alzheimer's disease. So far, to our knowledge, no large-scale genetic study of dementia with Lewy bodies has been done. To better understand the genetic basis of dementia with Lewy bodies, we have done a genome-wide association study with the aim of identifying genetic risk factors for this disorder.

Methods

In this two-stage genome-wide association study, we collected samples from white participants of European ancestry who had been diagnosed with dementia with Lewy bodies according to established clinical or pathological criteria. In the d

SUBMITTER: Guerreiro R 

PROVIDER: S-EPMC5805394 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature