Association between TNF-α-238G/A gene polymorphism and OCD susceptibility: A meta-analysis.

ABSTRACT:

Background

Tumor necrosis factor-alpha (TNF-α) is an important cytokine and has been reported to be associated with the pathogenesis of many autoimmune and inflammatory diseases. TNF-α gene is located on a region that has been found to be associated with obsessive-compulsive disorder (OCD). We performed this meta-analysis to assess the relationship between susceptibility to OCD and the TNF-α-238G/A gene polymorphism.

Methods

An extensive search of the available literature on the association between the susceptibility to OCD and the TNF gene polymorphism was conducted by searching PubMed, Web of Knowledge, Embase, Chinese Web of Knowledge, Wanfang, and Chongqing VIP database. The database was searched up to December 2016 and includes language of English and/or Chinese with th

SUBMITTER: Jiang C 

PROVIDER: S-EPMC5805438 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature