Sildenafil Improves Vascular and Metabolic Function in Patients with Alzheimer's Disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is the leading cause of degenerative dementia in the aging population. Patients with AD have alterations in cerebral hemodynamic function including reduced cerebral blood flow (CBF) and cerebral metabolic rate. Therefore, improved cerebrovascular function may be an attractive goal for pharmaceutical intervention in AD.

Objective

We wished to observe the acute effects of sildenafil on cerebrovascular function and brain metabolism in patients with AD.

Methods

We used several novel non-invasive MRI techniques to investigate the alterations of CBF, cerebral metabolic rate of oxygen (CMRO2), and cerebrovascular reactivity (CVR) after a single dose of sildenafil administration in order to assess its physiological effects in patients with

SUBMITTER: Sheng M 

PROVIDER: S-EPMC5805465 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature