Identification and characterisation of NANOG+/ OCT-4^high/SOX2+ doxorubicin-resistant stem-like cells from transformed trophoblastic cell lines.

ABSTRACT: Treatment of gestational trophoblastic diseases (GTD) involves surgery, radiotherapy and chemotherapy. Although, these therapeutic approaches are highly successful, drug resistance and toxicity remain a concern for high risk patients. This Chemoresistance has also been observed in the presence of cancer stem cells that are thought to be responsible for cases of cancer recurrence. In this study, we report the presence of previously unknown populations of trophoblastic stem-like cells (SLCs) that are resistant to the chemotherapeutic drug doxorubicin. We demonstrate that these populations express the stem cell markers NANOG and Sox2 and higher levels of OCT-4 (NANOG+/OCT-4^high/SOX2+). Although chemoresistant, we show that the invasive capacity of these trophoblastic SLCs is signif

SUBMITTER: Balahmar RM 

PROVIDER: S-EPMC5805535 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature