Vitamin D receptor Taq I polymorphism and the risk of prostate cancer: a meta-analysis.

ABSTRACT: Numerous previous studies reported the association of Vitamin D receptor gene Taq Ipolymorphism with prostate cancer risk, however these results were controversial. In order to provide a relatively comprehensive description of this relationship, we conducted this meta-analysis by searching PubMed, Embase, and China National Knowledge Infrastructure. Finally, 36 studies with 8,423 cases and 8,887 controls were included. Taq I polymorphism was found to marginally increase the prostate cancer risk in recessive genetic model (tt/Tt vs. TT: Odds Ratio (OR) = 0.89, 95% Confidence Interval (CI) = 0.80-1.00, p = 0.05) and allele genetic model (t vs. T allele: OR = 0.91, 95% CI = 0.84-0.99, p = 0.003) in the overall analysis. Subgroup analyses showed that significant inc

SUBMITTER: Kang S 

PROVIDER: S-EPMC5805542 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature