Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges.

ABSTRACT: Traditional cell culture and animal models utilized for preclinical drug screening have led to high attrition rates of drug candidates in clinical trials due to their low predictive power for human response. Alternative models using human cells to build in vitro biomimetics of the human body with physiologically relevant organ-organ interactions hold great potential to act as "human surrogates" and provide more accurate prediction of drug effects in humans. This review is a comprehensive investigation into the development of tissue-engineered human cell-based microscale multiorgan models, or multiorgan microphysiological systems for drug testing. The evolution from traditional models to macro- and microscale multiorgan systems is discussed in regards to the rationale for recent global effo

SUBMITTER: Wang YI 

PROVIDER: S-EPMC5805562 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature